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Thursday, May 25

> 8:00
Registration - start
> 8:00 - 11:30
DFG mast cell project meeting 
> 12:00 - 13:00 
EMBRN Executive committee meeting
> 14:00 
Marcus Maurer, President of EMBRN
Petr Dráber, on behalf of the local organizing committee
> 14:30 - 15:15 
Keynote lecture I:
Petr Dráber (Academy of Sciences of the Czech Republic, Czech Republic)
“Sphingolipid and Leukotriene Biosynthesis Is Regulated by ORMDL3-5-Lipoxygenase Cross-Talk”
> 15:15 -16:15 
Session I: Plasma membrane receptors and MC&Ba signaling 
(chaired by Toshiaki Kawakami and Petr Dráber)
   15:15 - 15:35
Toshiaki Kawakami  (La Jolla Institute for Allergy and Immunology, USA) 
“Differential contributions of mast cells vs. basophils via FcεRI to allergic diseases”
   15:35 - 15:55 
Silvia Bulfone-Paus (University of Manchester, UK)
“Strategies to inhibit excessive mast cell functions”
   15:55 - 16:15
Michael Huber (University Clinic Aachen, RWTH Aachen University, Germany) 
“Control of antigen-triggered mast cell activation by FcεRI-interacting membrane proteins”
> 16:15 - 16:45 
Coffee break
> 16:45 - 17:41 
Young researcher session I, Plasma membrane receptors and MC&Ba signaling 
(chaired by Toshiaki Kawakami and Petr Dráber).
   16:45 - 16:52
Ivana Halova
“Enhanced Mast Cell Chemotaxis in the Absence of Transmembrane Adaptor Protein NTAL towards Prostaglandin E2 is Regulated by AKT/ERM/β1-integrin Axis"
   16:52 - 16:59
Edismauro Freitas-Filho
“RACK1 Affects F-actin Dynamics and Modulates Preformed Mediator Release in Mast Cells”
   16:59 - 17:06
Mathias Gast
“Antibody-Independent Co-Aggregation of FcεRI and CD32 Results in Lyn- and SHIP1-Dependent Phosphorylation of CD32”
   17:06 - 17:13
Sabine Bühner
“Nerve-Mast Cell Interaction in The Human Intestine”
   17:13 - 17:20
Bernhard Gibbs
“New Insights into the Intracellular Control of Human Basophil Response”
   17:20 - 17:27
Axel Lorentz
“AMP-Activated Protein Kinase Modulates Circadian Clock Gene Expression in Human Mast Cells”
   17:27 - 17:34
Kia J. Puan
“The IgE-Mediated Signalling Pathway in Human Basophils is Based on Positive Feedback to Syk Phosphorylation”
   17:34 - 17:41
Elin Rönnberg Höckerlind
“IL-33 and TSLP Down Regulate FcεRI on Human Mast Cells”
> 17:45 - 19:45 
Poster viewing and discussion with Czech Beer
Evening: free  

Friday, May 26

> 8:30 - 
Registration - cont.
> 9:00 - 9:45
Keynote lecture II:
Geneviève de Saint-Basile (Inserm U768; CHU Hôpital Necker Enfants-Malades, France)
 “From monogenic immune disorders to the exocytosis of cytotoxic vesicles”
> 9:45 - 10:45
 Session II: MC&Ba exocytosis and mediators
 (chaired by Ulrich Blank and Ronit Sagi-Eisenberg)
   09:45 - 10:05
Ronit Sagi-Eisenberg (Tel Aviv University, Israel) 
“Regulation of mast cell secretory granule biogenesis and exocytosis”  
   10:05 - 10:25
Ulrich Blank (Inserm U 1149 & CNRS ERL8252, Université Paris-Diderot, France)
“Molecular mechanisms regulating late signaling events in IgE-mediated mast cell degranulation” 
   10:25 - 10:45
Pavel Dráber (Academy of Sciences of the Czech Republic, Czech Republic)
“Microtubular network and mast cells exocytosis”
> 10:45 - 11:15
Coffee break
> 11:15 - 12:25 
Young researcher session II, MC&Ba exocytosis and mediators 
(chaired by Ulrich Blank and Ronit Sagi-Eisenberg)
   11:15 - 11:22
Lucie Potuckova 
“CSK Regulates FcɛRI-Mediated Degranulation and Cytokines/Chemokines Responses in Opposite Ways, Independently of the Adaptor Protein PAG”
   11:22 - 11:29
Fabio Rabelo Melo 
“Tryptase-Catalyzed Core Histone Truncation: A Novel Epigenetic Regulatory Mechanism in Mast Cells”
   11:29 - 11:36
Aida Paivandy
“The Role of Reactive Oxygen Species in Mast Cell Death in Response to Granule Permeabilization”
   11:36 - 11:43
Lars Hellman
“Highly selective cleavage of cytokines and chemokines by the human mast cell chymase and human neutrophil cathepsin G”
   11:43 - 11:50
Viviana Valeri
“Mast Cells and B Cells Bidirectional Cross-Talk: Mutual Support in Homeostasis and Inflammatory Conditions”
   11:50 - 11:57
Gunnar Pejler
“Acidic pH Is Essential for Maintaining Mast Cell Secretory Granule Homeostasis”
   11:57 - 12:04
Ofir Klein 
“Actin Remodeling as Coordinator of Mast Cell Responses”
   12:04 - 12:11
Annet Babirye
“The Opposite Role of Inteferones In Allergic Inflammation”
   12:11 - 12:18
Chloe Rose
“Basophil Enrichment: How Does a Microfluidic Platform Compare to Current Experimental Procedures?”
   12:18 - 12:25
Mariam Bagher
“LAD2 Mast Cell Line and Mast Cell Tryptase Have Migratory Effect On Human Fetal Fibroblasts”
> 12:30 - 14:00 
Lunch buffet (hall)
> 14:00 - 14:45
Keynote lecture III
Stephen J Galli (Stanford University School of Medicine, USA)
“Why do we have mast cells?: Figuring out what mast cells do (and how they do it)”
Introduction: Marcus Maurer (Charité - Universitätsmedizin Berlin, Germany)
> 14:45 - 15:45
Session III: MC&Ba in diseases 
This session is dedicated to Steve Galli in honor of his 70th Birthday
The session will feature contributions by Galli lab members and ex-members
(chaired by: Marcus Maurer and Mindy Tsai)
   14:45 - 15:05
Nicolas Gaudenzio (Stanford University School of Medicine, USA) 
“Dynamic imaging of mast cell degranulation during inflammatory reactions”
   15:05 - 15:25
Laurent Reber (Institut Pasteur, France)
"Mast cell-dependent and -independent pathways of anaphylaxis"
   15:25 - 15:45
Michele Grimbaldeston (OMNI-Biomarker Development, Genentech Inc., USA) 
“Mast Cells: New insights into regulating their function”
> 15:45 - 16:15
Coffee break
> 16:15 - 17:11 
Young researcher session III: MC&Ba in diseases
(chaired by Marcus Maurer and Mindy Tsai)
   16:15 - 16:22
Miroslava Kardosova
“The Transcription Factor C/EBPγ Regulates Mast Cell Development and Function”
   16:22 - 16:29
Chiko Shimbori
“The Effect of Fibrotic Extracellular Matrix on Mast Cell Functions and Characteristics”
   16:29 - 16:36
Katarina Lyberg
“Mast Cells Derived From Patients With Systemic Mastocytosis Show Altered Micro RNA Profile and Osmotic-Induced Hyperreactivity”
   16:36 - 16:43
Magnus Åbrink
“Targeting Metastasis in Mammary Carcinoma: Functional Analysis of Serglycin Proteoglycan (and mMCP-4)”
   16:43 - 16:50
Yvonne Hagenlocher
“Mast Cell Amount and Degranulation Are Higher in Proximal Colon of IL-10-/- Compared to Wild Type Mice and Correlate With Disease Activity Index of Colitis”
   16:50 - 16:57
Mirjana Grujic
“The Combined Action of Mast Cell Chymase, Tryptase and Carboxypeptidase A3 Protects Against Melanoma Colonization of the Lung”
   16:57 - 17:04
Tomas Paulenda 
“Sphingolipid-regulated circuits in mast cell activation and inflammatory bowel disease”
   17:04 - 17:11
“Involvement of Cytonemes as a New Extracellular Antimicrobial Mechanism of Mast Cells”
> 17:15 - 19:15:
Poster viewing and discussion with Czech wine
>19:15 - 00:00
 Social event at IMG

Saturday, May 27

> 8:30 -
 Registration - cont.
> 9:00 - 9:45
Keynote lecture IV:
Hydar Ali (University of Pennsylvania School of Dental Medicine, USA)
“Mas-Related G protein coupled Receptor X2 and Mast Cells”.
> 9:45 - 10:45
 Session IV:  MC&Ba in diseases as targets for drug treatment 
(chaired by Frank Redegeld and Francesca Levi-Schaffer)
   9:45 - 10:05
Francesca Levi-Schaffer (The Hebrew University of Jerusalem, Israel) 
“Stop the mast cells by any means: the struggle against allergic diseases”.
   10:05 - 10:25
Frank Redegeld (Utrecht University, The Netherlands) 
“Role of mast cells in non-atopic diseases”.
   10:25 - 10:45 
Pio Conti (University of Chieti-Pescara, Italy)
 “Mast cell, cytokines and inflammation".
> 10:45 - 11:15 
Coffee break
> 11:15 - 12:11 
Young research session IV: MC&Ba in diseases as targets for drug treatment 
(chaired by Frank Redegeld and Francesca Levi-Schaffer)
   11:15 - 11:22
Nadine Landolina
“Activation of Siglec-7 Downregulates Transformed Human Mast Cell Leukemia Survival In Vitro”
   11:22 - 11:29
Zuzana Hájková 
“Miltefosine Modulates Both Cell Activation and Microtubule Dynamics in Bone-Marrow Derived Mast Cells”
   11:29 - 11:36
Flavie Ngo Nyekel
“Mast Cells Orchestrate Immune Cell Responses During Skin Graft Rejection”
   11:36 - 11:43
Vrinda Mohta
“Targeting MAPK Pathways in Mast Cell Leukemia”
   11:43 - 11:50
Thomas Wilhelm
“Bortezomib-Induced Switch from Adaptive to Terminal Unfolded Protein Response is Facilitated by JNK Inhibition In HMC-1.2 Cells”
   11:50 - 11:57
Yingxin Yu
“Crosstalk Between Human Mast Cells and Colon Cancer Cells Contributes to Colon Cancer Development”
   11:57 - 12:04
Sylwia Sekula-Neuner
“Mast Cell Chip: Combining Chemistry, Lithography and Biology”
   12:04 - 12:11
Lionel Rohner
“IL-3 Extends Bcl-2 Driven Spontaneous Survival of Basophils by de novo Synthesis of Bcl-xL and Mcl-1”
   12:11 - 12:18
Judah A. Denburg
“TSLP and In Situ Basophilopoiesis in Allergic Inflammation”
> 12:20 - 13:30 
EMBRN General Assembly 
> 13:30  
Farewell and Departure